770 LONG-TERM PROGNOSIS IN LVNC CARDIOMYOPATHY: A SINGLE-CENTRE EXPERIENCE

Abstract Background left ventricular non-compaction (LVNC) cardiomyopathy is an often underdiagnosed and under-classified disease deriving from the incomplete development of myocardium. Clinical presentations may be variable uncommon, ranging apparent lack functional anomalies to heart failure, arrhythmias and, in some cases, even ischemic stroke. Despite great improvements diagnostic performance there still a widespread evidence regarding prognosis management affected patients. Methods all consecutive patients admitted our Cardiology Institution October 2009 August 2022 fulfilling LVNC criteria by echocardiography or cardiovascular magnetic resonance (CMR) both, were consecutively enrolled. CMR has been performed wherever possible. All underwent complete cardiological visit, 12-lead ECG at baseline, whereas follow-up, if visit was not possible, information patients’ endpoints acquired through telephonic contact. Additional exams implantation cardiac device also indicated. The primary endpoint composite least one between: sustained arrhythmias, appropriate ICD intervention sudden death. Secondary included supraventricular unplanned hospitalizations, acute decompensated, chronic failure Risk predictor analyses as overall event rates low risk for type II error high. Results forty (26 males; age 45±17) prospectively enrolled followed up median five years. agreeing on majority diagnoses, with 62.5% meeting echo 70% LVNC. incidence 1.8% per Male gender late gadolinium enhancement (LGE) correlated increased endpoint, while LVEF, NC/C status associated significantly endpoint. HF diagnosis most common (6.1% annual incidence). 3.0% stroke 0.7%. Twenty-four (60%) experienced hospitalization during follow-up. Unplanned hospitalizations represented 20% mainly HF-related. Planned elective procedures such atrial fibrillation cardioversion, ablation, coronary angiography check-ups. Discussion LVNC, cardiac-related outcomes than general population; furthermore, male myocardial fibrosis are events. This trend highlights importance prompt obviously, correct knowledge disease.